WebJun 1, 2011 · Recent studies in Thailand and Taiwan showed a significant association between phenytoin (PHT)-induced SJS and human leucocyte antigen HLA-B*1502 … WebMay 28, 2014 · The HLA‐B*1502 allele was present in 2 (25.0%) of phenytoin‐induced SJS/TEN cases and 5 (41.7%) of the phenytoin‐tolerant controls tested positive for HLA‐B*1502 allele.
Association between HLA-B*1502 allele and antiepileptic drug …
WebHLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. WebDec 11, 2014 · A recent study has shown a significant association between the human leukocyte antigen (HLA) allele HLA-B*1502 and phenytoin-induced SJS in patients of … fit bharat movement
Cost-effectiveness of HLA-B*1502 genotyping in adult patients …
WebHuman leukocyte antigen (HLA) gene region encodes a set of HLA molecules functioning critical roles in immune response. Each HLA gene locus shows extensive polymorphism with ever-increasing number of alleles. The HLA nomenclature system for alleles defined by DNA typing was first established in 1987 and has been revised several times. Recently, it … WebHLA-B*1502. The life-threatening cutaneous side effect Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) occurs more frequently in patients with this genetic variation. The calculated risk of phenytoin-induced SJS/TEN in patients with HLA-B*15:02 is 0.65%. Carefully weigh the risk of SJS/TEN against the benefits An HLA-B*15:02 negative test does not eliminate the risk of phenytoin-induced … For the major histocompatibility complex region, variations in genes such as HLA … www.ncbi.nlm.nih.gov canfield ferguson mo