WebMar 28, 2024 · Overexpression of influenza virus NS1 protein, which inhibits nuclear polyadenylation through an interaction with the 30-kDa subunit of nuclear CPSF, … There is polyadenylation in the cytosol of some animal cell types, namely in the germ line, during early embryogenesis and in post-synaptic sites of nerve cells. This lengthens the poly(A) tail of an mRNA with a shortened poly(A) tail, so that the mRNA will be translated. These shortened poly(A) tails are often … See more Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that … See more Function In nuclear polyadenylation, a poly(A) tail is added to an RNA at the end of transcription. On mRNAs, the poly(A) tail protects the mRNA molecule from enzymatic degradation in the cytoplasm and aids in … See more For many non-coding RNAs, including tRNA, rRNA, snRNA, and snoRNA, polyadenylation is a way of marking the RNA for degradation, at least in yeast. This polyadenylation is … See more Although polyadenylation is seen in almost all organisms, it is not universal. However, the wide distribution of this modification and the fact that it is present in organisms from all three domains of life implies that the last universal common ancestor of all living organisms, it … See more RNAs are a type of large biological molecules, whose individual building blocks are called nucleotides. The name poly(A) tail (for … See more Many protein-coding genes have more than one polyadenylation site, so a gene can code for several mRNAs that differ in their 3′ end. The 3’ region of a transcript contains many polyadenylation signals (PAS). When more proximal (closer towards 5’ end) … See more In many bacteria, both mRNAs and non-coding RNAs can be polyadenylated. This poly(A) tail promotes degradation by the degradosome, which contains two RNA-degrading … See more

(PDF) Specificity factors in cytoplasmic polyadenylation

WebThe cytoplasmic polyadenylation element binding proteins are important for translation regulation, and CPEB3 is specifically responsible for binding a novel translation-regulating signal that consists of a stem-loop with a U-rich bulge. 99,100 Expression of CPEB3 occurs in a wide range of tissues and is increased in mouse hippocampus following … WebFeb 6, 2024 · Cytoplasmic polyadenylation, which is one of the posttranscriptional regulations, plays a crucial role in RNA metabolism. Here, we report that Cpeb1b-mediated cytoplasmic polyadenylation is... shutterfly cell phone cases

Translational control by CPEB: a means to the end

WebCPEB, or cytoplasmic polyadenylation element binding protein, is a highly conserved RNA -binding protein that promotes the elongation of the polyadenine tail of messenger … WebAug 15, 2024 · The cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates the translation of several mRNAs important for long-term synaptic plasticity in the hippocampus. In previous studies, we found that the oligomerization and activity of CPEB3 are controlled by small ubiquitin-like modifier (SUMO)ylation. the painting spot