Cisplatin with mannitol

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August undefined, 2024

WebBackground Cisplatin-induced nephrotoxicity is a dose limiting adverse effect that occurs in nearly one-third of patients. Mannitol administration has been used as a means to negate this toxicity. Data regarding the efficacy of mannitol use in this context are … WebJan 31, 2012 · Mannitol plus hydration has been used for several years to alleviate toxicity associated with cisplatin therapy. However, the data for mannitol administration have not been convincing. When the use of mannitol and hydration is compared directly to hydration alone, mannitol shows no benefit.

Renal function of cancer patients "fit" for Cisplatin ... - PubMed

WebCisplatin with mannitol appeared to be less toxic than pure cisplatin, and carboplatin the least toxic. Even carboplatin produced significant threshold shifts, particularly at high frequencies, but they were not accompanied by hair cell loss. Values of EP were not different from those in normal control animals. MeSH terms WebFeb 16, 2016 · Cisplatin is standardly dosed in a three-weekly schedule of 100 mg/m 2 (total dose 300 mg/m 2) combined with standard RT [ 3, 6, 7, 9, 10 ]. However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity). port kashdin mcsherry cortland ny

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebJan 7, 2024 · Cisplatin is used as treatment for several different malignancies and a well-known complication is irreversible kidney damage. To protect the kidneys, this treatment … WebCisplatin for injection has been administered at 75 mg/m. 2 . to 100 mg/m. intravenously per cycle once every 3 to 4 weeks on Day 1. Other doses and … WebApr 12, 2024 · All doses of cisplatin were diluted in 500 ml of 0.9% saline and infused over 2–3 h. Patients in the mannitol cohort received 20 g admixed in the 0.9% 100 ml saline prehydration. All patients received antiemetic premedication such as dexamethasone, a H 2 receptor blocker and diphenhydramine. Assessment of outcome port karamouth

Administering Mannitol With Hydration and Premeds

WebTwenty-two patients with advanced neoplasms refractory to conventional therapy were treated with cisplatin at a dose of 100 mg/m2 every 21--28 days. Patients were randomized to receive 37.5 g of mannitol by 6-hour infusion with cisplatin or 40 mg of furosemide prior to cisplatin therapy. WebJan 1, 1980 · Calibration curves of cisplatin were prepared as stock solutions of cisplatin accurately weighed and dissolved in a diluent composed of sodium chloride and … port karsonmouthWebMannitol combined with hydration significantly prevented cisplatin-induced nephrotoxicity. Therefore, mannitol should be considered among patients with cancer, treated with … port kariannemouth

"WebAug 13, 2024 · Clinical studies have shown that using mannitol along with Cisplatin chemotherapy reduces Cisplatin-induced kidney injury, an adverse side-effect seen in a … " - Cisplatin with mannitol

Cisplatin with mannitol

Cisplatin: Outpatient and office hydration regimens - ScienceDirect

WebJun 23, 2024 · Our cisplat goes in 250 mls usually giving us a final volume of 340 mls. We used to pass Mannitol concurrently but that's now been stopped as it's no longer deemed beneficial. We give 2 litres post hydration supplementing in potassium, magnesium and calcium. Obviously we modify in the case of frail elderly patients or known cardiac failure. WebFigure 1. An example of chemotherapy regimen: cisplatin and pemetrexed. - "Short hydration in chemotherapy containing cisplatin (≥75 mg/m2) for patients with lung cancer: a prospective study."

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WebJan 7, 2024 · Cisplatin is used as treatment for several different malignancies and a well-known complication is irreversible kidney damage. To protect the kidneys, this treatment is often combined with mannitol infusion to promote osmotic diuresis. Earlier studies investigating the nephroprotective effect of mannitol have shown conflicting results. … WebObjective: We aimed to evaluate the rates of cisplatin-induced nephrotoxicity in cancer patients receiving single-agent cisplatin with and without mannitol. Methods: This single-center retrospective analysis was a quasi experiment created by the national mannitol shortage. Data were collected on adult cancer patients receiving single-agent ...

WebMannitol plus hydration has been used for several years to alleviate toxicity associated with cisplatin therapy. However, the data for mannitol administration have … WebWith hydration and mannitol diuresis, patients with ECOG 2, normal creatinine, CKD stage 3 or better, CrCl of 50ml/min and above are "fit" for cisplatin. During the study period, 9% of the patients "fit" for cisplatin developed nephrotoxicity, all resolved with conservative management. There was an …

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf Webwww.ncbi.nlm.nih.gov

WebCisplatin can affect the kidneys. To help prevent kidney damage: you will be given extra fluids through the drip before and after the cisplatin you may be given a drug called mannitol which is given as a drip. Or you may be given a drug called furosemide, which is given as a tablet or an injection.

WebJun 10, 2024 · Herein, we combined a derivative of cisplatin (CP) and the chemosensitizer lonidamine (LND) to design an amphiphilic prodrug, in which the ratio of LND to cisplatin was fixed at 2:1. Diaminedichlor... irobot iphoneWebFeb 1, 1987 · The exact mechanism of mannitol protection is un- known; however, it possibly prevents immediate binding of cisplatin onto the renal tubule proteins. In addition, while mannitol has not been shown to be of greater benefit than liberal fluid administra- tion alone, its use will usually allow the adminis- tration of a greater fluid volume. port karinamouthWebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the administration of cisplatin, mannitol (20%, 200 ml) was administered as forced diuresis over 30 min. And magnesium sulfate (8 mEq) was added to pre-hydration. Results port kalebmouth port karleymouthWebCisplatin DRUG NAME: Cisplatin SYNONYM: CDDP ,1 cis-Diamminedichloroplatinum 2dichlorodiammineplatinum(II) 3 Patinum II DDP 4. COMMON TRADE NAME: ... Others suggest hydration with NS, hypertonic saline infusion, and mannitol, or furosemide-induced diuresis to effectively decrease cisplatin-induced nephrotoxicity. 7. port kaylimouthWebApr 4, 2024 · Cisplatin + gemcitabine (Category 1) 40,41 (nasopharyngeal) Days 1 and 8: Gemcitabine 1,000mg/m 2 IV. Days 1–3: Cisplatin 80mg/m 2 IV in divided doses. Repeat cycle every 3 weeks. irobot j7 plus owners guideWebJun 27, 2016 · Conclusion. The use of mannitol reduces the incidence and severity of nephrotoxicity in patients treated with cisplatin. The results of the study suggest … irobot issues